Make the Roux: Melt 2 tablespoons of butter in a pan over medium-high heat. Add 2 tablespoons of all-purpose flour and whisk until a blonde roux forms, about 1 minute.
Add Milk: Slowly drizzle in 1 cup of whole milk while whisking until a thick sauce forms.
Add Cheeses: Stir in 4 oz each of cheddar and Monterey Jack cheese, and 4 oz of Parmesan cheese over low heat until melted.
Prepare Breadcrumbs: In another pan, melt 2 tablespoons of butter over medium-high heat and add 1 cup of panko breadcrumbs. Cook until golden.
Combine and Bake: Par-cook your pasta, combine with the cheese sauce, and top with the breadcrumb mixture. Cover and bake at 450°F for 10 minutes, then uncover and bake for an additional 10-15 minutes until browned and crispy.